Is 25 mg Benadryl safe for dogs?

Benadryl Dose for Dogs Plumb's Veterinary Drug Handbook recommends giving a standard dosage of 25 milligrams for a 25-pound dog two to three times per day. As a general rule of thumb, use 1 milligram per pound of your dog's body weight. For example, a 50-pound dog would be given two 25 milligram tablets.



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Benadryl® may make some dogs a little sleepy and less responsive, but it doesn't do anything for their underlying anxiety. Benadryl® does has some efficacy in the prevention of motion sickness in dogs.

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The effects of the medication typically last for around 6-8 hours. Liquid Benadryl is typically recommended for dogs weighing less than 10 pounds, as this can make it easier to achieve an accurate and appropriate dose.

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If using Benadryl as a mild sedative for motion sickness or any sort of thunderstorm or travel anxiety, it's best to think ahead so you can plan out when you give it to your doggo. It will usually take 30 minutes for Benadryl to take full effect, and you want your pup calm and anxious-free.

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Common side effects of Benadryl include constipation, sedation, urinary retention, diarrhea, vomiting, increased heart rate, and loss of appetite for some dogs. Always be sure to monitor your dog closely when giving medication for the first time.

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It usually takes Benadryl about 15 to 30 minutes to start working. The effects of Benadryl tend to last for 4 to 6 hours, but the medication can stick around in the body for much longer. Since Benadryl can make you sleepy, it can be best to take it in the evening.

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