No, Buckingham Palace is significantly larger than the Biltmore House. While the Biltmore Estate in Asheville, North Carolina, is the largest privately-owned home in the United States, it measures approximately 178,926 square feet and contains 250 rooms. In contrast, Buckingham Palace in London spans roughly 828,821 square feet and boasts 775 rooms. This makes the British royal residence nearly 4.6 times larger in terms of floor area than the Vanderbilt mansion. When comparing the "estates" as a whole, the Biltmore Estate originally covered 125,000 acres (now about 8,000 acres), while Buckingham Palace sits on a 40-acre site in the heart of London. While Biltmore feels like a massive French chateau, Buckingham Palace operates more like a small city, housing offices, a post office, a cinema, and a medical facility, which accounts for its vast lead in square footage.