Yes, it is safe. But most shops close up about 5 or 6 PM (except restaurants). A few touristy shops stay open later. No need to even consider walking around at night as there really is not too much to see or experience then.
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The crowds are generally more manageable around Chinatown in the late morning or early afternoon. If you want to grab a memento or some gifts for family and friends back home, it's best to get to the shops along Grant Street right when they open to avoid the inevitable crowds.
In general yes.But how late depends on the area. SF like any big city has it's problem areas, so always have someone with you and avoid obvious looking areas and people that may or may not be OK. I have walked around late to take pics, but never alone.
The Marina District and Fisherman's Wharf seem to be the best choices for a tourist to feel safe in San Francisco. These places are located near the main tourist attractions, so you will find a lot to do nearby. It will also be easy to walk around.
After a string of attacks by people masquerading as drivers, the city's district attorney wants passengers to beware. Dara Kerr was a senior reporter for CNET covering the on-demand economy and tech culture.