NSAIDs (non- steroidal anti- inflammatory drugs) and analgesics acetaminophen (Tylenol) aspirin (Bayer's) ibuprofen (Advil/Motrin) naproxen (Naprosyn) Advil PM, Tylenol PM (Most “PM” medications contain diphenhydramine) Most OTC pain meds are safe to fly as long as the underlying condition is acceptable.