It may look bad to take sick time immediately after a vacation, but it is far worse to show up at the office with the flu and potentially spread the disease. See how you're feeling when you get home and call in sick if you need to.
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Take time to decompress
It is just as important to reset your mind after your vacation as it is to reset your body. Take time to unwind and process all the unique experiences you had. Unpack and unclutter your house, but don't make your to-do list the first week back home too long.