Yes, driving from Dubrovnik to Split is widely considered safe and is one of the most scenic road trips in Europe. The route primarily follows the D8 Adriatic Highway (Jadranska magistrala), which is well-maintained but can be narrow and winding in certain coastal sections. As of 2026, the Pelješac Bridge is fully operational, allowing you to bypass the Neum corridor in Bosnia and Herzegovina entirely, meaning you no longer have to worry about border crossings or passport checks midway through the drive. While the coastal road is safe, it requires focused driving due to the cliffs and summer traffic. For a faster, albeit less scenic, alternative, the A1 Motorway provides a modern, multi-lane toll road experience that connects the two regions in approximately 3 to 3.5 hours.