Whether it is safe to eat fish from the St. Johns River in Florida depends entirely on the species and location, as the Florida Department of Health (FDOH) maintains ongoing "consumption advisories" due to mercury and other contaminants. As of 2026, the general population is advised to limit meals of many popular species like Largemouth Bass and Channel Catfish to one meal per week (or even less for children and women of child-bearing age) due to bioaccumulated mercury levels. Some urban tributaries, particularly near Jacksonville, are heavily polluted with E. coli and industrial chemicals, making fish caught there strictly "catch and release." However, "healthy" populations of species like Redfish and Spotted Seatrout in the cleaner, brackish lower basin are generally safe to eat within the FDOH limits. It is crucial to consult the current Florida Fish Consumption Guidebook for the specific "Planning Unit" where you are fishing. To reduce risk, the FDOH suggests removing the head, guts, and skin, and avoiding pan-frying or deep-frying, which can trap chemicals in the fish's fat.