Yes, it is safe and legal to take a box of wine on a plane, but it must be packed in your checked luggage. Because a box of wine (typically 3 liters) exceeds the 3.4 oz (100ml) limit for carry-on liquids, it cannot go through the security checkpoint. Under FAA and TSA 2026 guidelines, wine is not considered a "hazardous material" because its alcohol content is well below 24% (usually around 12–14%). However, to ensure it is "safe" for your clothes, you should place the box in a sturdy, leak-proof plastic bag to prevent any spills if the bag is handled roughly. Also, be mindful of your airline's weight limit; a full box of wine weighs about 7 lbs (3.2 kg). Never attempt to drink your own wine on board, as FAA regulations strictly prohibit consuming alcohol not served by a flight attendant.