It's a ghost town at night and quite far from all of the famous Paris sites. Is La Defense safe? Yes, it generally is a safe area, but it is still part of a large city so, as always, pay attention in large urban areas.
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The Eiffel Tower's lighting and sparkling lights are protected by copyright, so professional use of images of the Eiffel Tower at night requires prior authorization and may be subject to a fee.
The Champs-Elysées is very lively and not too risky, at least during the day. You should still be careful on this large avenue, especially at night because it's so crowded that it is the perfect place for pickpockets.
It's not a dangerous area. A young lady alone at night might attract some unwanted attention but even then, if you keep walking, no one will bother you. There are always plenty of people about.
It depends on where you would like to go. Paris Gare du Nord is quite safe. There are a lot of people there and even late at night I never had to worry about safety, BUT, do not attract attention with a big camera or any other stuff that can make you look like a tourist.
The Chapel is the only place in the Vatican that photography and filming are completely banned. Undoubtedly one of the world's most famous buildings, the Sistine Chapel is a testament to the immense skill of history's greatest artists within the Renaissance era.
You needn't ascend the Tower twice, but you'll definitely want to see it at 10 p.m. when the lights sparkle. A good time to ascend the Tower is shortly before twilight, so you can experience it at sunset and also after dark.
Visiting the Eiffel Tower in the evening and at night is a completely different experience to day tours – and just as much of a must-see experience! In particular, climbing the stairs while the structure is lit up from the inside offers a unique ambiance that you don't want to miss.