No, the storyline of Manifest is entirely fictitious; the inspiration for the plot came from the mystery surrounding Malaysia Airlines Flight 370.
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Flight 828 was trapped within a divine consciousness where the higher power divvied out the Callings in order to prevent a volcanic apocalypse. That explained that the dreaded Death Date was never connected to the passengers at all, rather, it was referring to this aforementioned apocalypse.
Flight 828 was a service of Montego Air from Montego Bay, Jamaica to John F. Kennedy International Airport, New York, New York. The aircraft departed on April 7, 2013 carrying a total of 191 passengers and crew. The flight encountered turbulence while airborne and arrived over New York on November 4, 2018.
It provides an explanation for one of the longest running TV mysteries. The supernatural drama chronicles the lives of a group of aeroplane passengers whose flight mysteriously vanished from the face of the earth for five-and-a-half years.