The Masai Mara is located in a malaria-endemic region, but the actual risk level is often considered "moderate" rather than "high" due to its elevation. Situated at roughly 1,500 to 2,000 meters above sea level, the Mara is cooler and less humid than Kenya's coastal areas, which slightly inhibits mosquito activity. However, malaria-carrying Anopheles mosquitoes are still present, especially during and immediately after the rainy seasons (March–May and November–December). Most travel clinics and health organizations, including the CDC and WHO, strongly advise visitors to take malaria prophylaxis (such as Malarone, Doxycycline, or Lariam) before, during, and after their trip. Beyond medication, the "best defense" is physical prevention: wearing long-sleeved clothing and trousers at dusk and dawn, using insect repellents containing at least 30% DEET, and sleeping under the mosquito nets provided by virtually all lodges and camps. While the risk is manageable with proper preparation, it should never be ignored, as malaria can be a life-threatening illness. Always consult a travel medicine specialist at least 6 weeks before your safari to discuss the most appropriate preventative measures for your specific health profile.