It's the second-largest station in Italy, behind Roma Termini. There are 24 tracks at Centrale, with a soaring glass and metal arched roof over the platforms. There is regular daily service to cities throughout Italy, as well as international destinations in other parts of Europe.

Milano Centrale is not only one of the largest train stations in Italy but also one of the most architecturally significant in Europe. Inaugurated in 1931, it serves as a major hub for over 320,000 passengers daily and handles roughly 500 trains, including high-speed, regional, and international services. The station's massive steel-and-glass roof, designed by Alberto Fava, spans 72 meters in its central arch, which was the largest of its kind in Italy at the time of construction. Beyond its functional scale, the station is a "platform palace" filled with monumental sculptures, decorative friezes, and over 80 shops and restaurants across multiple levels. Its sheer size can be overwhelming for first-time visitors, with its vast galleries and long distances between the main entrance and the tracks (binari), making it a true landmark of 20th-century eclectic architecture.