Red-eye flights are not dangerous. If anything, they are safer because there is less air traffic during that time frame. Assuming the crew are properly rested (which is a concern for all time frames), then everything else is just fine.

Red-eye flights—those departing late at night and arriving early the next morning—are statistically just as safe as daytime flights. Aviation safety is governed by strict international regulations that do not vary based on the time of day. While human fatigue is a known factor in aviation, airlines employ Fatigue Risk Management Systems (FRMS) to ensure pilots and cabin crew receive mandatory rest periods and are fit for duty. Modern aircraft are also equipped with advanced autopilot and night-vision instrumentation that allow for safe navigation in total darkness. In fact, flying at night can sometimes be smoother because air traffic is lighter and there is often less thermal turbulence than during the heat of the day. For passengers, the main "risk" is not safety but rather physical exhaustion and jet lag, as the shorter duration of many domestic red-eyes makes it difficult to achieve a full sleep cycle. As long as the crew adheres to rest requirements and the aircraft undergoes its standard maintenance, flying at midnight is a perfectly safe way to travel.