If you're young and adventurous you might like Shibuya more. If you are around retirement age perhaps you might prefer Ginza. But it might depend more on actual hotels.
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The lively hub of Shibuya is arguably the youth heart and soul of the city, and unmissable if you're visiting the Tokyo area. With world-famous sights including the iconic scramble crossing, this area is a must-see for nightlife and trendy youth culture.
The daytime hustle retreats, replaced by a nocturnal allure that captivates night owls, adventurers and insomniacs alike. Shibuya's nighttime offerings are both a visual and sensory adventure, from quirky bars nestled in hidden alleyways to panoramic views of the city lights.
There are really no really no go areas, even red light areas of Kabukicho in Shinjuku have tons of tourist visiting nowadays, crime towards visitors are low, the only real way you get into trouble is if you are looking for trouble yourself.
Harajuku (?? in Japanese) is a station located between Shibuya and Shinjuku on the JR Yamanote loop line around central Tokyo. Many people get off the train at Harajuku Station to visit such popular spots as Yoyogi Park, Meiji Shrine and Omotesando, a boulevard of luxury brands and other high-end shopping experiences.
The areas with the largest number of crime incidents, namely Shinjuku, Setagaya, and Edogawa, are also areas with a comparatively high population. Likewise, few people live in the low-crime areas of Bunkyo, Meguro, and Arakawa.
If you were asked to say some things that came to mind when you thought of Tokyo's wondrous metropolis, it's unlikely you would think of Sanya. A small area that straddles Taito-Ku and Arakawa-Ku area situated south around Yoshino-Dori. Japan has tried very hard over the decades to hide the slums of Tokyo.
Who do you think it's best for? Anyone remotely impressed that Tokyo is the most populated city in the world should visit Shibuya Crossing. The best time to go is at dusk, one of the scramble's peak times and in its most flattering light.