Pseudoephedrine-containing medicines are authorised in various EU Member States alone, or in combination with medicines to treat symptoms of a cold and flu such as headache, fever and pain, or allergic rhinitis (inflammation of the nasal passages) in people with nasal congestion.

Sudafed and other medicines containing pseudoephedrine are legal in Europe, but as of late 2024 and through 2026, they are subject to much stricter regulations. In many EU countries, including France, pseudoephedrine-based oral decongestants now require a medical prescription and are no longer available over-the-counter (OTC). This change was driven by the European Medicines Agency (EMA) to minimize risks of rare but serious side effects like PRES and RCVS. In the United Kingdom, you can still buy certain Sudafed products OTC, but they are kept "behind the counter," and the pharmacist must perform a consultation to ensure suitability. Travelers should be aware that some countries have very strict laws regarding "precursor" chemicals; while personal use amounts (one or two boxes) are rarely an issue for tourists, carrying large quantities could be scrutinized. Always keep the medication in its original packaging with a copy of your prescription to avoid any complications at customs in stricter jurisdictions.