As stated in other answers, in steady flight there is no pressure difference along the length of the cabin, and only a miniscule one during lognitudinal acceleration.
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Usually, it's best to pick a seat toward the front of the plane for several reasons: It's usually quieter, and you can get on and off faster. There's a balance between choosing front/back and window/aisle.
Rear sectionThe back of the plane is definitely the worst place to sit for travelers who hate turbulence since it's far from the plane's center of lift and gravity. This section can also be very loud since some planes have engines and auxiliary power units toward the back of the body that make a lot of noise.
While people usually aren't clamoring to get those back middle seats, this shows they do have at least one advantage! Logically, the safety of these seats makes sense. Seats at the back of an airplane are close to exit rows while providing more cushion from any collisions that may impact the front of the plane first.
The best seatIf a traveler sits towards the front of the wings so that the engines are behind them, not only will they feel less turbulence, but they'll also have a quieter flight.
“The smoothest place to sit is over the wings,” commercial pilot Patrick Smith, host of AskThePilot.com said. These seats are close to the plane's center of lift and gravity. “The roughest spot is usually the far aft. In the rearmost rows, closest to the tail, the knocking and swaying is more pronounced,” Smith added.
The worst seats on an airplane for turbulence are the jump seats in the back of the plane, where the flight attendants sit, followed by the passenger seats towards the back of the aircraft.
The back of the plane usually feels bumpier than anywhere else in the plane, because it's further away from the centre of mass of the aircraft. So if you're closer to the front or near the wings, then you usually feel less turbulence.
The back of the plane is definitely the worst place to sit for travelers who hate turbulence since it's far from the plane's center of lift and gravity. This section can also be very loud since some planes have engines and auxiliary power units toward the back of the body that make a lot of noise.
So many travelers struggle with this fear, so the best way to cope is to find a seat with plenty of space. The least crowded section of the plane is first or business class. But if upgraded flying isn't in your budget there are still options. Try sitting in an aisle seat in an exit row towards the front of the plane.
If airplanes didn't pressurize their cabins, it could lead to insufficient oxygen as well as related medical problems like hypoxia. Airplanes need pressurized cabins because it ensures passengers, as well as crew members, receive an adequate amount of oxygen in the air they breathe.