While the route between Pisa and Florence is one of the busiest in Italy, it is not served by "High Speed" (Alta Velocità) trains like the 300 km/h Frecciarossa. Instead, it is served by Regionale and Regionale Veloce trains operated by Trenitalia. These trains are efficient and frequent, with departures roughly every 15 to 20 minutes during peak hours. The "Regionale Veloce" (Fast Regional) makes fewer stops and completes the journey between Pisa Centrale and Firenze Santa Maria Novella in approximately 50 to 60 minutes. In 2026, the ticket price remains very affordable, typically costing around €9 to €10. Because these are regional trains, you do not need to book a specific seat in advance, and tickets do not sell out; you can simply buy one at a kiosk or via the app and board the next available train. While you won't experience the "bullet train" speeds found on the Milan-Rome line, the regional service is the "backbone" of Tuscan travel, offering a reliable, scenic, and cost-effective way to move between the Leaning Tower and the birthplace of the Renaissance.