All Amtrak trains, Thruway buses and stations are entirely non-smoking. No one may smoke anything in any area on trains, on Thruway services, in stations or in any other location where smoking is prohibited.

In 2026, it is virtually impossible to smoke inside any commercial train anywhere in the world due to global fire safety regulations and public health laws. Modern trains are equipped with sensitive smoke and heat detection systems that can trigger alarms, emergency braking, or fire suppression protocols, leading to significant delays and heavy fines for offenders. This prohibition almost universally extends to electronic cigarettes and vaping devices as well. The only "way" to smoke while traveling by rail is to utilize designated "Smoking Stops" at specific stations during longer journeys. For instance, Amtrak and several European long-distance carriers allow passengers to step off the train onto the platform for a few minutes if the schedule permits and local laws allow it. However, passengers must remain immediately next to the train and be ready to re-board as soon as the horn sounds. Attempting to smoke in a train lavatory is especially dangerous and illegal, as the confined space quickly triggers sensors, and in 2026, many operators have implemented high-definition CCTV in vestibules to identify and prosecute individuals who violate these safety-critical rules.