Producing a vacuum means removing air from the contents of a package. Oxygen in environmental air does promote certain reactions in foods which cause deterioration of quality.
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Using vacuum bags does not make your luggage heavier — packing 30 pounds of clothing will still be 30 pounds whether compressed or not. However, you may find that your suitcase ends up heavier since the vacuum bag will open up more space, allowing you to pack more items.
Vacuum packing reduces atmospheric oxygen, limiting the growth of aerobic bacteria or fungi, and preventing the evaporation of volatile components. It is also commonly used to store dry foods over a long period of time, such as cereals, nuts, cured meats, cheese, smoked fish, coffee, and potato chips (crisps).
Rolling clothes will not make your bag heavier—unless you pack more because of all of the space you saved! So be careful of overpacking. Instead of rolling to save space, roll clothes so that you can downside to a carry-on bag and enjoy a bag that weighs a lot less.