Zofran (Ondansetron) is an extremely powerful anti-emetic originally designed for chemotherapy-induced nausea, and while it is highly effective at stopping the act of vomiting, it is not always the best choice for preventing the underlying "dizzy" sensation of sea sickness. Unlike Scopolamine (the patch) or Meclizine (Dramamine Less Drowsy), Zofran does not treat the inner-ear "sensory conflict" that causes motion sickness; it primarily works by blocking serotonin signals in the gut and brain that trigger the gag reflex. Many maritime doctors in 2026 prescribe it as a "rescue medication" for when a passenger is already actively ill and cannot keep oral pills down, often in an ODT (orally disintegrating tablet) form. However, because it doesn't address the vestibular cause, you may still feel "woozy" even if you aren't throwing up. It is also a prescription-only medication in most countries, including the US and UK. For a more comprehensive approach, travelers often combine a preventative (like a Scopolamine patch) with Zofran as a backup. Always consult a physician before use, as Zofran can cause side effects like headaches or constipation and may interact with other medications.