According to the research done by American Chiropractic Association, it is dangerous to carry heavy bags on one shoulder. One's bag should not weigh more than 10% of one's body weight.
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One of the clearest signs that a strapped bag is too heavy is seeing a bright red mark on your shoulder at the end of the day. Sometimes the area may even appear indented. If this is the case, you definitely need to lighten your bag as soon as possible.
It's extremely important to avoid regularly carrying more than 15 percent of your body weight. Children or smaller people are especially at risk because they typically carry heavier loads in proportion to their weight.