Should I take an aspirin before a long flight?

Taking aspirin to prevent blood clots when traveling is not recommended. If you take aspirin for other reasons, check with your doctor.



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Aspirin? Taking 75mg (a quarter of a normal 300mg tablet) some hours before your flight may reduce your chances of a DVT slightly (but remember that Aspirin can sometimes cause indigestion in people with a tendency to it, if in doubt ask your GP);

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Your GP will not be able to advise on the use of anticoagulants for flying as it is a specialist issue, so allow plenty of time to get an opinion from your specialist. Note: aspirin is not used to prevent DVT.

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Talk to your doctor about wearing compression stockings or taking medicine before departure if you have additional risk factors for blood clots. Taking aspirin to prevent blood clots when traveling is not recommended. If you take aspirin for other reasons, check with your doctor.

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Prevent Blood Clots During Travel
  1. Stand up or walk occasionally. ...
  2. Exercise your calf muscles and stretch your legs while you're sitting. ...
  3. Talk to your doctor about wearing compression stockings or taking medicine before departure if you have additional risk factors for blood clots.


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Research has shown that wearing compression socks during long-haul flights can significantly reduce the risk of developing blood clots and alleviate symptoms of leg fatigue and discomfort.

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DVT or PE may manifest during or shortly after the flight, but often not for several weeks. Prevention includes choosing aisle seating, maintaining hydration, walking frequently, wearing loose clothing, exercising the lower extremities, using a foot rest, and avoiding alcohol and sleeping pills.

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What Are the Best—And Safest—Sleeping Pills for Flights?
  • Ambien. Ambien—the most powerful option on this list and the only one that requires a prescription—works as a sedative-hypnotic medication that slows your brain activity to make you feel very sleepy. ...
  • Tylenol PM. ...
  • Melatonin.


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The plasma half-life of aspirin is only 20 minutes; however, because platelets cannot generate new COX, the effects of aspirin last for the duration of the life of the platelet (˜10 days). After a single dose of aspirin, platelet COX activity recovers by ˜10% per day as a function of platelet turnover.

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