Dramamine is an over-the-counter preventative drug that can help with motion sickness while flying. Although this medication can cause severe drowsiness, it can help you sleep through your flight instead of feeling the unfortunate common symptoms. Eat food that is low in sodium and fat a few hours before your flight.

You should take Dramamine (dimenhydrinate) before a flight if you are prone to motion sickness, but you must time it correctly for it to be effective. For the best results, you should take it 30 to 60 minutes before your journey starts. Once you already feel nauseated from turbulence, the medication is far less effective. Dramamine works by blocking the signals in the brain that trigger nausea and dizziness. However, be aware of the side effects: the "Original Formula" is an antihistamine that causes significant drowsiness, which can be a "pro" if you want to sleep on the flight but a "con" if you need to be alert upon landing. In 2026, many travelers prefer the "Less Drowsy" (meclizine) version, which lasts 24 hours and is less likely to leave you feeling groggy. Always consult a healthcare provider first if you are taking other medications or have underlying health conditions.