Should I take melatonin on a flight?

Taking a melatonin supplement when you first get on a flight— if traveling overnight—is a great way to ease yourself to sleep, so you wake up refreshed and rested when you land. However, this should only be done for flights longer than 6 hours, as this is how long it takes melatonin to leave your system.



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But here's what one paper recommends based on multiple studies: For eastbound flights up to 9 hours long: Prepare before the flight: Take 5 mg of melatonin, wake up earlier, and get bright light exposure. Day of the flight: take 5 mg of melatonin at 6 p.m.

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As for taking sleeping pills on a plane, Oexman does not advise it. With pills like Ambien, people may find themselves sleepwalking or acting erratically with no knowledge.

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These include any hormone-based drugs, like the contraceptive pill and some fertility medicines, and drugs used to prevent heart attack and stroke. Antihistamines should also not be used to help passengers sleep during a flight.

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What Are the Best—And Safest—Sleeping Pills for Flights?
  • Ambien. Ambien—the most powerful option on this list and the only one that requires a prescription—works as a sedative-hypnotic medication that slows your brain activity to make you feel very sleepy. ...
  • Tylenol PM. ...
  • Melatonin.


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“If you're landing when people are awake in the middle of the day, that's what you want to do, too. Sleep as much as you can on the plane,” she says. “If you're going to be landing at night, do your best to stay awake on the plane and sleep at your destination.”

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Melatonin pills and gummies are totally fine to take on a plane from a TSA (Transportation Security Administration in the USA) perspective, but liquid melatonin has its own requirements (explained below).

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Yes, you can bring medications on a plane. But traveling with medicines requires extra planning. Medications may need additional screening in airport security. However, passengers should be able to bring all prescribed medicines and medical supplies onto the airplane.

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They include:
  • Anti-anxiety medication, such as diazepam (Valium) or alprazolam (Xanax).
  • Motion sickness medication, such as dimenhydrinate (Dramamine).


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