Delta Air Lines is currently the largest operator with 65 airplanes in its fleet. As of September 2023, A330 orders stood at 1,809 of which 1,582 had been delivered and 1,466 were in service with 145 operators. The global A330 fleet had accumulated more than 60 million flight hours since its entry into service.

As of early 2026, Delta Air Lines is the largest operator of the Airbus A330 family, particularly the new A330-900neo. Following a significant order for 31 widebody aircraft in January 2026, Delta's A330 fleet is projected to grow to 55 A330neo aircraft alone, in addition to their existing older A330-200 and -300 models. Other major operators include Turkish Airlines and China Eastern Airlines, both of which maintain massive fleets of the A330 for their medium-to-long-haul networks. The A330's popularity in 2026 is driven by its exceptional fuel efficiency (especially the "neo" version) and its versatile capacity, which allows airlines like Delta to serve trans-Atlantic and trans-Pacific routes with lower operating costs compared to larger four-engine jets or even the Boeing 777.