The IOTV backpack is the standard issue for U.S. forces and has built-in MOLLE webbing on which special forces can attach extra equipment like pouches or even other backpacks, like daypacks or rucksacks.

The US Army currently utilizes the Modular Lightweight Load-carrying Equipment (MOLLE) II system as its primary load-bearing setup. The core of this system is the MOLLE II Large Rucksack, which offers approximately 5,000 cubic inches of storage and is designed to handle heavy combat loads with a rugged plastic frame. For shorter missions lasting 24 to 72 hours, soldiers are typically issued the MOLLE II Medium Rucksack or the Assault Pack. These backpacks are characterized by their "PALS" (Pouch Attachment Ladder System) webbing, allowing soldiers to customize their gear by attaching modular pouches. In 2026, many units have also transitioned to the Integrated Visual Augmentation System (IVAS) compatible packs, which feature specific cable routing and battery compartments. While "Assault Packs" are common for daily tasks, the "Large Ruck" remains the standard for field training and extended deployments, often appearing in the "Operational Camouflage Pattern" (OCP).