Those with schizotypal personality disorder tend to feel uncomfortable and have a difficult time in social circumstances, although they may still be friendly towards others. In the film Taxi Driver, Robert De Niro's character Travis Bickle seems to be suffering from this disorder.

In the classic 1976 film Taxi Driver, the protagonist Travis Bickle is portrayed as a deeply troubled individual suffering from several psychological conditions. The most prominent is chronic insomnia, which drives him to take the night shift as a taxi driver to cope with his inability to sleep. He also exhibits clear symptoms of Post-Traumatic Stress Disorder (PTSD) stemming from his service as a Marine in the Vietnam War. Psychiatrists and film critics often analyze his character as having Schizotypal Personality Disorder, evidenced by his extreme social isolation, distorted perceptions of reality, and eccentric "savior" delusions. His profound sense of alienation and loneliness in the "corrupt" urban environment of New York leads to a slow descent into paranoia and radicalization. Travis's lack of social filters and his increasing obsession with "cleansing" the city reflect a mind fractured by trauma and the failure of society to reintegrate its veterans effectively.