Today, Biltmore remains a family business, with the fourth and fifth generations of George Vanderbilt's descendants involved in day-to-day operations.

The Vanderbilt family descendants, specifically the Cecil family, are the owners and caretakers of the Biltmore Estate in Asheville, North Carolina. While George Washington Vanderbilt II originally built the massive 250-room mansion in 1895, it is no longer used as a full-time private residence for the family. George’s grandson, William A.V. Cecil, was instrumental in turning the estate into the major tourism enterprise it is today. Currently, George Vanderbilt's great-grandson, Bill Cecil Jr., serves as the CEO of the Biltmore Company, and his sister, Dini Pickering, is the Chairman of the Board. While the family members have private residences on the vast 8,000-acre grounds, they do not "live" inside the historic Biltmore House itself, which has functioned primarily as a public museum and tourist attraction since 1930. The family remains deeply committed to the estate’s preservation and self-sustaining business model, which includes a winery, several hotels, and a working farm, continuing the legacy of "scientific forestry" and agricultural innovation started by their ancestor.