The most common side effects include sleepiness, dry mouth, and difficulty urinating. Other less common side effects include diarrhea, vomiting, and lack of appetite. Serious side effects include seizures and coma, and may indicate an overdose.
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If your dog is a working dog, be aware that they will likely be sedated and lethargic during their normal routines and assignments while taking Dramamine. Also, if your dog has an antihistamine allergy, the medication could be dangerous for them, since it's an antihistamine.
Dimenhydrinate is safe for dogs but tends to have more sedative properties than meclizine. Sometimes this is ok if you want your dog to sleep the drive away. But other times you may want something that allows your dog to remain more alert. This may make meclizine or Cerenia a better choice.