For best protection, you are encouraged to use supplemental oxygen above 10,000 feet MSL. At night, because vision is particularly sensitive to diminished oxygen, a prudent rule is to use supplemental oxygen when flying above 6,000 feet MSL.
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In aeronautics, hypoxia typically results from a decompression or lack of pressurisation of the aircraft cabin. Hypoxia occurs within a few minutes if the cabin pressure altitude rises to between 5,000-6,000 m (about 16,000 - 20,000 ft).
Importance to MembersAnd that at cabin altitudes above 14,000 feet pilots must use oxygen at all times. And that above 15,000 feet each occupant of the aircraft must be provided supplemental oxygen. All of this is spelled out in Federal Aviation Regulations Part 91.211.
Gradual and progressive onset during flight above 10,000 feet altitude in the absence of normal pressurisation. This can arise either by climb above 10,000 feet without the pressurisation system functioning, or because of pressurisation system malfunction.