What is an airplane pill?

Ambien (zolpidem) is among the most popular — and potent — sleeping pills for travel. Classified as a sedative-hypnotic drug, Ambien works by slowing down your brain, making it easier for you to fall asleep.



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What Are the Best—And Safest—Sleeping Pills for Flights?
  • Ambien. Ambien—the most powerful option on this list and the only one that requires a prescription—works as a sedative-hypnotic medication that slows your brain activity to make you feel very sleepy. ...
  • Tylenol PM. ...
  • Melatonin.


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Those longer acting medications should be avoided for short flights. For example, you wouldn't want to use a long-acting medication like Ambien on a short flight. Why? You could find yourself too groggy to take care of yourself when you arrive at your destination or during an emergency, he said.

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Alprazolam in a 0.5 mg dose is prescribed for both jet lag and flight anxiety. It initiates the sleep cycle at the right time, alleviates anxiety, and does not have a hangover effect due to its very short half life. It is an addictive medication when taken in larger doses, and must be used very sparingly.

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While Xanax may be useful for flying on an airplane, it will not help you with your anxiety. It may help in the moment but you will not tackle your fear of flying if you are asleep the whole flight. If you ran out of your medication or left it at home, the anxiety will still exist if you go on an airplane again.

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