The primary difference is the scope of travel. TSA PreCheck is designed for domestic security within the US; it allows you to keep your shoes, belts, and light jackets on, and keep your laptop and liquids in your bag. Global Entry is for international travelers returning to the US; it allows you to bypass the traditional customs line and use an automated kiosk/facial recognition. A supportive peer "travel" hack: Global Entry actually includes TSA PreCheck. In 2026, Global Entry costs $120 (recently increased) for five years, while PreCheck is $78. If you plan to leave the country even once in the next five years, it is well worth the extra money to get Global Entry, as you get both benefits for a single application. Both require an in-person interview, but Global Entry's background check is slightly more thorough.