Occasionally, aircraft with a seating structure of 2+2 may letter the seats as ACDF to keep with the standard of A/F being window and C/D being aisle on short-haul aircraft (which generally have 3+3 seats).
Specifically, pick a window seat on the left side of the aircraft. These seats are usually off-center, making leaning up against the side of the plane more comfortable. A bulkhead seat is also a great option because you don't have to worry about anyone reclining into your space.
The window seats offer the best views and minimal disruptions from your row mates. Ultimately, you'll be the disruptive one when it's your turn to visit the lavatory, but still, the window seat gives you that undisturbed solitude to make it through your flight without interacting.
If you prefer to sit on the aisle, the best aisle seats are those in the centre section of the plane. If the plane has a 3-4-3 configuration, sitting on the aisle of the centre section means there will be fewer passengers needing to move past you to access to the toilet or to stretch their legs.
Aisle seats What are they? This type of ticket, named after the seats that are located on the side of an aisle and offer greater comfort to the spectator, will be available for sale in certain sections of some events.
Some airlines may skip some letters because some of the letters are absent from their alphabet (e.g. an airline in Vietnam may have the layout ABC-DEG-HKL in economy class because letters f, j, w, and z are absent from the Vietnamese alphabet).