What is the best antihistamine to take before flying?

If you suffer from allergies, consider a non-sedating antihistamine instead, such as loratadine (Claritin®) or fexofenadine (Allegra). Claritin and Allegra do not have wait times (after the initial ground trial).



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Many pilots are unaware that there are wait times after each use of sedating antihistamines. For cetirizine (Zyrtec®) and levocetirizine (Xyzal®), you should not fly for 48 hours after taking the last dose. For diphenhydramine or doxylamine, you should not fly for 60 hours after taking the last dose.

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If Benadryl® is the only medicine you find that can provide relief for your cold, allergy, or sleep symptoms and you feel you cannot give it up, you should wait at least five (5) half-lives before getting in the cockpit. Benadryl's® half-life is quite long, up to 10 hours.

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These include any hormone-based drugs, like the contraceptive pill and some fertility medicines, and drugs used to prevent heart attack and stroke. Antihistamines should also not be used to help passengers sleep during a flight.

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These drugs are usually taken shortly before a flight. They include: Anti-anxiety medication, such as diazepam (Valium) or alprazolam (Xanax). Motion sickness medication, such as dimenhydrinate (Dramamine).

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Flight anxiety medication
  • fluvoxamine (Faverin)
  • citalopram (Celexa)
  • escitalopram (Lexapro)
  • paroxetine (Paxil)


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People often come to us requesting the doctor or nurse to prescribe diazepam for fear of flying or assist with sleep during flights. Diazepam is a sedative, which means it makes you sleepy and more relaxed.

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Does the FAA have a list of prescription and over-the-counter drugs that pilots can and cannot take while flying?
  • Tranquilizers, such as but not limited to Valium, Librium, Ativan.
  • Most antidepressants. ...
  • Opiates, such as Morphine, Codeine, Lortab, Percodan, Oxycontin.
  • Muscle relaxants, such as Soma, Sonata, Flexeril.


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Your doctor can prescribe you a type of medication known as benzodiazepine, which can calm the nervous system. The most well-known examples are Xanax and Ativan, which act within minutes to relieve anxiety. They last several hours — which is the duration of most cross-country flights, such as Los Angeles to New York.

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If you have any allergy or cold-related symptoms, make sure you take an antihistamine or decongestant spray at least 30-45 minutes before your flight. Following this method can help alleviate any additional sinus pressure.

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Exposure therapy: This type of therapy gradually exposes you to places, thoughts or situations that relate to air travel. You may visit an airport and watch planes arrive and depart. Virtual reality tools, such as computer simulations of flights, can also help you overcome your fear of flying.

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She told the group what worried her. “I am afraid of dying.” Fear of flying, or aviophobia, is an anxiety disorder.

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1) Diazepam is a sedative, which means it makes you sleepy and more relaxed. If there is an emergency during the flight it may impair your ability to concentrate, follow instructions and react to the situation. This could have serious safety consequences for you and those around you.

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10 Tips for Plane Travel
  1. Drink more water. Hydration will help you handle anything air travel sends your way. ...
  2. Drink less alcohol. Alcohol presents a double threat to airplane wellness. ...
  3. Pack for hydration. ...
  4. Prepare your immune system. ...
  5. Flex your calves. ...
  6. Stretch everything else. ...
  7. Sleep near the window. ...
  8. Make your own legroom.


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