However, if you do have a choice, and considering what I pointed out above, the best time to visit Rome would be mid-week: a tad less crowded (depending on the season), and shops, restaurants and museums tend to be open during mid-week.
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On Sunday, the city comes alive with locals and tourists alike, taking in the sights and sounds of the city. From the thrift stores and interesting local museums, to the stunning monuments and churches, a stroll around this city is sure to be a memorable experience.
Best Time To Visit The Roman ColosseumEarly hours or just before closing - During the day, visit either right at the Colosseum opening hours or just before it closes. One to two hours in the morning is quite pleasant and less crowded. For this, you will have to arrive at least 30 minutes before the opening time.
Sunday morning Masses are:7am ; 8am ; 9am ; *10.30am and 12pm. * The Sunday Solemn Mass is celebrated at 10.30am. To get a seat in the Solemn Mass you will need to be inside the Basilica by 9.30am. You will also need to make allowances for the time it takes to get through security into the church.
There is some planning and preparation involved, but attending the Papal Audience is a truly unique experience that's well worth the effort (it was my favorite thing I did in Rome!) Read on for a full guide to attending an outdoor Papal Audience at the Vatican.