What is the best medicine for travel anxiety?

Pharmacological treatment These drugs are usually taken shortly before a flight. They include: Anti-anxiety medication, such as diazepam (Valium) or alprazolam (Xanax). Motion sickness medication, such as dimenhydrinate (Dramamine).



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Physicians can prescribe medications as needed for flight anxiety. The most common class includes benzodiazepines like Xanax and Ativan, which are relatively fast-acting to relieve anxiety and stay in the body for several hours, which is the duration for most cross-country flights.

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Anxious While Traveling? 7 Tips for Coping with Travel Anxiety
  1. Identify triggers.
  2. Research.
  3. Prepare.
  4. Ground yourself.
  5. Practice self-care.
  6. Focus on positives.
  7. Talk it out.
  8. Next steps.


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Though there's no one cause for travel anxiety, some common ones are fear of flying, fear of crowds, fear of crashing, fear of social interactions, fear of guns, fear of disease (insert Covid here), and, perhaps biggest of all, fear of the unknown and being outside your comfort zone.

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Travel anxiety is the fear of visiting an unfamiliar place. It can also involve the stress that comes with planning your travels. Even if you have no history of anxiety, the idea of being outside familiar territory can throw you into panic mode.

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Medications for flight anxiety, like SSRIs and SNRIs, can help manage symptoms in addition to other treatments, like exposure therapy and CBT. Some medications can also help you with upsetting and sudden symptoms, including episodes of panic. It's best to talk with a doctor about your options for flight anxiety.

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People often come to us requesting the doctor or nurse to prescribe diazepam for fear of flying or assist with sleep during flights. Diazepam is a sedative, which means it makes you sleepy and more relaxed. There are a number of very good reasons why prescribing this drug is not recommended.

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1) Diazepam is a sedative, which means it makes you sleepy and more relaxed.

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Diazepam is a sedative, which means it makes you sleepy and more relaxed. There are a number of very good reasons why prescribing this drug is not recommended. According to the prescribing guidelines doctors follow (British National Formulary) diazepam is contraindicated (not allowed) for treating phobias (fears).

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Take it about two to three hours before you fly, and do not mix it with alcohol. There is a risk of dependency, though, with these benzodiazepines, but only if you are taking them more than once a week.

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People often come to us requesting the doctor or nurse to prescribe diazepam for fear of flying or assist with sleep during flights. Diazepam is a sedative, which means it makes you sleepy and more relaxed. There are a number of very good reasons why prescribing this drug is not recommended.

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Diazepam is a sedative. This means, the medication makes you sleepy and more relaxed. If there would be an emergency during the flight, this could impair your ability to concentrate, follow instructions, or react to the situation. This could seriously affect the safety of you and the people around you.

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Many fliers with anxiety find the easiest coping strategy is to just switch off. Some experts recommend sleeping aids, like pills, whereas others suggest herbal remedies like Kalms or Rescue Remedy.

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The two main medication classes most often prescribed are:
  • Benzodiazepines, such as the antianxiety drugs alprazolam (Xanax®), clonazepam (Klonopin®) and diazepam (Valium®).
  • Selective serotonin reuptake inhibitors, such as paroxetine (Paxil®) or escitalopram (Lexapro®).


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