What is the best prescription sleeping pill for flying?

Ambien (zolpidem) is among the most popular — and potent — sleeping pills for travel. Classified as a sedative-hypnotic drug, Ambien works by slowing down your brain, making it easier for you to fall asleep. It comes in two forms, Ambien and Ambien CR (controlled release), both of which require a prescription.



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“As this hormone usually helps us fall and stay asleep, the excessively bright lights on airplanes naturally make it hard to sleep well.” Even if the lights aren't bright enough to suppress melatonin, they can distract and irritate those trying to sleep.

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Read on for our science-backed strategies* for how to sleep on a plane.
  1. Stay at the right temperature. ...
  2. Wear bed socks. ...
  3. Power down your devices. ...
  4. Wear a light-blocking eye mask. ...
  5. Listen to pink noise. ...
  6. Wear noise-canceling headphones or earplugs. ...
  7. Uncross legs and use footrests. ...
  8. Lean backward with proper support.


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The night before, cheat yourself of a couple of hours of sleep—not more. This works well for very long flights that last long enough to get your usual hours of rest. For flights that are just a little too short for that, like a 5-hour run from New York to Paris, this tactic can be risky.

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Don't Pull an All-Nighter However, that sleep on the plane is never as good as the sleep you missed out on the night before. If you're somewhat rested and ready for a long journey, chances are you won't miss connections due to being rundown and listless from that all-nighter you pulled.

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Alprazolam in a 0.5 mg dose is prescribed for both jet lag and flight anxiety. It initiates the sleep cycle at the right time, alleviates anxiety, and does not have a hangover effect due to its very short half life. It is an addictive medication when taken in larger doses, and must be used very sparingly.

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Flight anxiety medication
  • fluvoxamine (Faverin)
  • citalopram (Celexa)
  • escitalopram (Lexapro)
  • paroxetine (Paxil)


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Use of Benzodiazepines (and related medications) for flying Initial use of benzodiazepines, including the well-known Diazepam also known as 'Valium', was enthusiastic and they were hailed as a wonder drug.

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While Xanax may be useful for flying on an airplane, it will not help you with your anxiety. It may help in the moment but you will not tackle your fear of flying if you are asleep the whole flight. If you ran out of your medication or left it at home, the anxiety will still exist if you go on an airplane again.

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People often come to us requesting the doctor or nurse to prescribe diazepam for fear of flying or assist with sleep during flights. Diazepam is a sedative, which means it makes you sleepy and more relaxed.

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Doctors rarely recommend sleeping tablets for flying for several reasons. Some tablets render you immobile, which would be problematic during an in-flight emergency. Even if you're OK with that small risk, avoid sitting near an emergency exit where you could be responsible for many lives in an emergency.

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Taking a melatonin supplement when you first get on a flight— if traveling overnight—is a great way to ease yourself to sleep, so you wake up refreshed and rested when you land. However, this should only be done for flights longer than 6 hours, as this is how long it takes melatonin to leave your system.

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