The most important holidays – with the most closures – are Christmas and Easter, followed by New Year's Day and Labor Day. Chiuso per Ferie means Closed for Holiday – a sign you're likely to see anytime there is a public holiday or in August!
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Italy's best travel months are May, June, September, and October. They're also the busiest and most expensive time to visit (with the north remaining just as busy throughout midsummer). Crowds aside, these months combine the convenience of peak season with pleasant weather.