The main difference between Global Entry and Nexus is that Global Entry allows for expedited reentry to the U.S. when returning from any country abroad. On the other hand, Nexus allows expedited passage between the U.S. and Canada.
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Canada recently launched a new, PreCheck-like program called “Verified Traveller,” offering expedited screening service at security checkpoints at a number of Canadian airports.
Your Known Traveler Number is your membership number with a Trusted Traveler Program. This number is what allows you to access TSA PreCheck security lanes and Global Entry lanes (depending on which Trusted Traveler Program you join).
There's no TSA PreCheck in Europe (womp womp), but at select Europe airports, travelers can reserve a time slot in advance (free of charge) then head to the front of the security line. There's no need to experience a repeat of last year's flightmare at Amsterdam's Schiphol.