What is the first line for travelers diarrhea?

Although loperamide is the recommended first-line agent, patients should be informed that if the diarrhea worsens or is accompanied by moderate-severe or invasive symptoms (1 or more of fever, moderate to severe abdominal pain or bloody diarrhea), then antibiotics should be used (Table 2).



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Call a doctor if you have diarrhea that is severe, lasts more than a few days or is bloody. If you are traveling, call an embassy or consulate for help locating a doctor. Other signs that you should seek medical attention include: A fever of 102 F (39 C) or higher.

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Learn some ways to treat travelers' diarrhea
  1. Drink lots of fluids. If you get diarrhea, drink lots of fluids to stay hydrated. ...
  2. Take over-the-counter drugs. Several drugs, such as loperamide, can be bought over-the-counter to treat the symptoms of diarrhea. ...
  3. Only take antibiotics if needed.


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Traveler's diarrhea may get better without any treatment. But while you're waiting, it's important to try to stay hydrated with safe liquids, such as bottled water or water with electrolytes such as an oral rehydration solution (see below).

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Travellers' diarrhoea usually gets better in 3 to 5 days. Most cases are mild and do not need specific treatment. For further information on self-treatment and when to seek medical help, see treatment section below.

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Try an over-the-counter medication for traveler's diarrhea like IMODIUM® A-D or IMODIUM® Multi-Symptom Relief.

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In serious cases of travelers' diarrhea, oral rehydration solution—available online or in pharmacies in developing countries—can be used for fluid replacements. Several drugs, such as loperamide, can be bought over-the-counter to treat the symptoms of diarrhea.

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