Sure, everyone knows that you have to use supplemental oxygen if you fly more than 30 minutes at cabin pressure altitudes of 12,500 feet or higher. And that at cabin altitudes above 14,000 feet pilots must use oxygen at all times.
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For operations conducted under Parts 121 and 135, the flight crew must use oxygen when cabin altitudes are above 10,000 up to 12,000 feet after 30 minutes and at all times when above 12,000 feet. The general aviation pilot flying an unpressurized airplane will not normally operate above 25,000 feet.
Many large widebodies have a ceiling of up to around 43,000 feet (12,500 meters). The Airbus A380, for example, is 43,100 feet and the A350 and Boeing 787 are the same (although the larger 787-10 and A350-1000 are lower at 41,100 feet and 41,450 feet).
Nevertheless, certain exceptional aircraft like the Concorde and the Tupolev Tu-144 have managed to ascend to altitudes of FL600 (equivalent to 60,000 feet).
The highest certified altitude of an airliner was Concorde's 60,000 feet. Today some of the corporate jets can fly at 51,000 feet. Q: What is the highest cruising altitude allowed? A: Most airliners are limited to 45,000 feet or less.
The most common reason is that there are no airstrips or airports on many of the small islands, so if a plane had to make an emergency landing, it would be difficult to find a place to land. Additionally, the Pacific Ocean is vast and remote, so if a plane were to go down, it would be very difficult to find.
In aeronautics, hypoxia typically results from a decompression or lack of pressurisation of the aircraft cabin. Hypoxia occurs within a few minutes if the cabin pressure altitude rises to between 5,000-6,000 m (about 16,000 - 20,000 ft).
A series of Navy and Air Force programs in the 1950s and 1960s used pressure vessels or pressure suits to get balloonists higher, some to above 100,000 feet. Skydiver Nicholas Piantanida set an unofficial record—123,500 feet—in 1966, but a later attempt went awry when his helmet depressurized.
It's quieter for people on the ground (planes can be loud), at altitude the air is less dense and the plane can fly faster & more efficiently, if the plane's flying above 18,000-20,000 ft, then it's above most of the weather.