As of 2026, the Wynn and Encore combined complex remains the largest casino floor in Las Vegas by total square footage, boasting approximately 193,500 square feet of gaming space. While many think of the MGM Grand as the behemoth—and it is the largest single-building hotel in the U.S. with over 5,000 rooms—its actual casino floor measures roughly 171,500 square feet, putting it in the second or third spot depending on how you measure the newer "integrated" floors. For a "pure" single-casino footprint on the Strip, the Aria (152,000 sq ft) and Bellagio (156,000 sq ft) are the other heavyweights. It is a high-value distinction for 2026 travelers: if you want the "world's largest" casino, you actually have to leave Vegas and head to the WinStar World Casino in Oklahoma, which is nearly three times larger than the Wynn at 600,000 square feet. In Vegas, "biggest" often refers to the entire resort footprint, but for strictly rolling the dice, the Wynn/Encore "twin" towers offer the most expansive and high-end playground in the city.