Taking the crown for the world's longest scheduled A320 route is Moscow Domodedovo to the rather hard-to-pronounce Blagoveshchensk, on the Chinese border and across the river from the Chinese city of Heihe. Blagoveshchensk is 3,492 miles (5,619 km) from Domodedovo.

The Airbus A320neo is primarily a short-to-medium-haul workhorse, but its impressive fuel efficiency has allowed it to push into long-haul territory. One of the longest scheduled commercial routes for the standard A320neo has historically been operated by IndiGo, flying between Delhi, India, and Istanbul, Turkey, covering a distance of approximately 4,550 km (2,827 miles) with a flight time of around 6.5 to 7 hours. However, the broader "A320neo family" includes the A321LR (Long Range) and A321XLR (Extra Long Range), which have completely redefined the limits for single-aisle jets. The A321LR regularly flies routes like Paris to Newark or Copenhagen to Washington D.C., reaching over 4,000 nautical miles. The A321XLR, which entered service recently, is capable of flights up to 11 hours long, such as Rome to New York or London to Delhi. While the base A320neo stays within the 6-7 hour range, it is the pioneer of the technology that now allows narrow-body planes to cross the Atlantic and connect distant continents non-stop.