Via Maqueda along with Via Vittorio Emanuele are probably the 2 main tourist pedestrianized areas in central Palermo. They cross at Quatro Canti and are packed with eating places and toursit shops.
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Yes, Palermo is very walkable and pedestrian friendly. The main streets such as Via Maqueda or Via Vittorio Emanuele are pedestrian areas and the city center is closed to cars without the city pass. Hence, you will be better off walking around Palermo rather that driving through it by car.
The extravagant piazza in the center of Palermo is Piazza Pretorio is home to the city's delightful fountain and other architectural gems. Named for the Palazzo del Pretorio, which was the ruling seat of power, the piazza was given a dubious nickname- Piazza of Shame.
There are good train services for parts of the islandThe main line runs east from Palermo to Messina and then south to Syracuse via Catania. Trains on these routes are fast and comfortable. A web of secondary lines with much slower trains and more limited service covers some other parts of the island.
April to early June and September to October are generally considered the best times to visit Palermo. During these months, the temperatures aren't as sweltering as they are in the summer months, and the region isn't as busy with tourists as it is during the summer.
Palermo's coastline features some of the most beautiful beaches in Sicily, including Mondello Beach. Catania's coastline is known for its stunning cliffs and bays, with several beaches like Playa di Catania that offer excellent swimming and snorkeling opportunities.