Matogianni Street is the main street in Mykonos town – Chora. It is located close to Little Venice and the Aegean Maritime Museum. The street's main appeal is that it is the center of all activity during the night and the day. Everything is painted white except the railings and window panes, which are blue or brown.

The most famous and iconic street in Mykonos Town (Chora) is Matoyianni Street (also spelled Matogianni). It serves as the main artery of the island's shopping and social scene, characterized by its narrow, winding cobblestone paths and brilliant whitewashed buildings with bright blue shutters and overflowing pink bougainvillea. During the day, it is a hub for high-end boutique shopping, featuring everything from local Greek jewelry to international luxury brands like Louis Vuitton and Dior. At night, Matoyianni transforms into a vibrant, high-energy thoroughfare where the "glitterati" and tourists alike mingle at chic cocktail bars and cafes. Because the entire town is a pedestrian-only zone, the street maintains an intimate, labyrinthine charm that is quintessentially Cycladic. While many visitors get "happily lost" in the surrounding side streets, Matoyianni remains the definitive "place to be seen" on the island, eventually leading travelers toward the picturesque "Little Venice" waterfront and the famous 16th-century windmills.