The upper deck features a third Business Class cabin with 8 rows of 32 seats, arranged in a 2-2 layout. Due to the 2-2 layout (contrary to the 2-2-2 layout on the lower deck), this cabin has a more intimate feel and is the best Business Class cabin. It almost feels a bit like flying in a private plane.

The upper deck of the Boeing 747-8 Intercontinental is the iconic "bubble" that makes the aircraft the "Queen of the Skies." In the passenger version, this deck is almost exclusively configured for Business Class, offering a highly private and quiet "boutique" atmosphere. For example, on Lufthansa's 747-8, the upper deck typically houses 32 Business Class seats in a 2-2 configuration. Because the deck is elevated and separated from the main cabin by a staircase, it experiences significantly less foot traffic and noise, making it a favorite for frequent flyers. The cabin walls are also slightly curved, providing unique storage bins at the window seats. While the 747-8 is no longer in production, it remains one of the few aircraft where passengers can experience the "exclusive" feeling of flying on a second level, separate from the primary economy and first-class sections.