Vacuum sealer manufacturers recommend that you do not package raw onions, fresh mushrooms or fresh garlic due to botulinum concerns. Some foods do not seal well, such as bakery foods and liquid products.
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Leather, silk, cashmere, thick wool garments, and any natural fiber materials that could be damaged by compression should not be vacuum sealed. This may include woven items, hemp, or items with feathers.
The National Center for Food Preservation warns that there are risks with vacuum sealed food products. Some harmful bacteria that only grow in air-free setting can grow much better and faster in vacuum sealed products than if they were not vacuum sealed.