What medication is used to relax before flying?

People often come to us requesting the doctor or nurse to prescribe diazepam for fear of flying or assist with sleep during flights. Diazepam is a sedative, which means it makes you sleepy and more relaxed.



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People often come to us requesting the doctor or nurse to prescribe diazepam for fear of flying or assist with sleep during flights. Diazepam is a sedative, which means it makes you sleepy and more relaxed.

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The two main medication classes most often prescribed are:
  • Benzodiazepines, such as the antianxiety drugs alprazolam (Xanax®), clonazepam (Klonopin®) and diazepam (Valium®).
  • Selective serotonin reuptake inhibitors, such as paroxetine (Paxil®) or escitalopram (Lexapro®).


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People often come to us requesting the doctor or nurse to prescribe diazepam for fear of flying or assist with sleep during flights. Diazepam is a sedative, which means it makes you sleepy and more relaxed.

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Official answer. Ativan and Xanax are both benzodiazepines used for the treatment of anxiety, and both are equally effective for this use. The differences are: Xanax has a quicker onset of effect, but a shorter duration of action (4 to 6 hours) compared with Ativan's 8 hours.

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For example, deep breathing or meditation during take-off, landing or turbulence can reduce your symptoms of anxiety. You can also learn to “talk back” to negative thoughts about flying when they arise.

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Also, if possible, travel with a supportive friend or relative. They can help you work through the anxiety, guide you through relaxation exercises, or simply keep you distracted. Your companion can also help manage details such as checking luggage, which you may feel uncomfortable handling.

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While Xanax may be useful for flying on an airplane, it will not help you with your anxiety. It may help in the moment but you will not tackle your fear of flying if you are asleep the whole flight. If you ran out of your medication or left it at home, the anxiety will still exist if you go on an airplane again.

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Dosage for anxiety The typical dose is 2 mg to 6 mg, divided into two or three doses per day. For example, if your daily dosage is 4 mg, you would take 2 mg once in the morning and once in the evening.

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Xanax, a member of the same pharmaceutical family (benzodiazepines) as diazepam, is a strong one. Take it about two to three hours before you fly, and do not mix it with alcohol. There is a risk of dependency, though, with these benzodiazepines, but only if you are taking them more than once a week.

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Over-the-counter options include Dramamine (bonus: it will also help if you have motion sickness), melatonin (a hormone that can help with sleep and prevent jet lag), any antihistamine containing diphenhydramine (such as Benadryl), and medicines designed for insomnia, like Unisom or ZzzQuil.

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Does Benadryl Help Anxiety? Although some people say that Benadryl helps their anxiety, it is not approved by the FDA for anxiety symptoms. Therefore, do not take it for anxiety unless your healthcare provider specifically recommends it. The only FDA-approved antihistamine for anxiety is hydroxyzine (Atarax, Vistaril).

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“Some of the primary reasons some people are afraid to fly are a fear of crashing, a fear of being out of control, a fear of the unknown, a fear of heights, having lost a loved one in a plane crash and feeling claustrophobic,” says Ora Nadrich, a certified mindfulness meditation instructor and life coach.

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She told the group what worried her. “I am afraid of dying.” Fear of flying, or aviophobia, is an anxiety disorder.

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