The easiest and quickest way to reach the Vatican Museums would be to take the Metro. Line A of the Metro will take you to Ottaviano-S.Pietro station, which is located right outside Vatican City.
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The Vatican has a dress code that some travellers might not be aware of when visiting. Luckily if you're planning on wearing jeans to the Vatican, you definitely can! When you plan to visit, it's best to keep your knees and shoulders covered. And for footwear, you will need flat shoes, not flip-flops or casual sandals.
The Vatican Museums allow visitors to bring bags that are no larger than 15.7 inch x 13.7 inch x 6 inch (40 cm x 35 cm x 15 cm). If your bag is larger or if you are carrying a long umbrella or camera tripods you will have to check in your items into the wardrobe at the entrance of the museums (the guide will help you).
What shoes to wear at the Vatican. There are no special rules about shoes at the Vatican and you can wear closed shoes or sandals. While there is no specific rule about wearing flip flops at the Vatican, it is good practice not to. Flip flopr are impractical for the location, often noisy and considered too casual.
Tickets currently cost €17 for adults and €8 for children between the ages of 6 and 18. Purchase tickets to see the Sistine Chapel in the Vatican Museums. You can skip the ticket line for an extra €5 per ticket. This is the same price charged for tickets purchased in advance.
The dress code for the Vatican Museums is strict but easy to respect. Low-cut or sleeveless dresses, miniskirts, shorts and hats are not allowed. To cover knees and shoulders you can buy plastic cloaks to wrap around. Inside it is preferable to wear long-sleeved shirts and long trousers.
There is a security check as you enter into the Vatican museums so it is important that you only bring a plastic bottle. Glass bottles will be taken from you or you will be forced to leave them in the locker room.
After lunch, visit Vatican Museums around 2pm — by the time you reach the iconic Sistine Chapel, close to the 6pm closing time, it'll be relatively empty.