In 2026, the earliest Shinkansen from Tokyo to Osaka (Shin-Osaka Station) typically departs at 06:00 AM. This is the first Nozomi train of the day (often Nozomi 1), which is the fastest service, taking approximately 2 hours and 22 minutes to complete the journey. There are often two departures right at 6:00 AM—one from Tokyo Station and one from Shinagawa Station—allowing business travelers to arrive in Osaka before 8:30 AM. If you are using a Japan Rail Pass, you would likely take the first Hikari train, which departs shortly after (around 06:21 AM) and takes roughly 3 hours. For 2026 travelers, it is highly recommended to book these "first trains" at least 24–48 hours in advance through the Smart EX app, as they are incredibly popular with commuters and frequently sell out, especially on Monday mornings.